My name is Dr. Coppola and I’m the creator of the formula NUPHORIA cm Gold. Along with Dr. Monteiro, we spent years of extensive research on safe, natural methods to support nerve repair and strengthen nerve function.

In the scientific studies, what we discovered is that complexing critical B vitamins, in conjunction with Alpha Lipoic Acid (a powerful antioxidant ) had proven capabilities to repair the damage of peripheral nerves, protect the nerves from future damage and support proper communication.

Over 100 clinical studies have been published in Medical journals proving that the combination of B1, B6, B12, Folic Acid and Alpha Lipoic Acid can assist with repairing damaged peripheral nerves and decrease symptoms of peripheral Neuropathy.

Before developing our unique formulation, we would prescribe one bottle of each of these separate supplements to our neuropathy patients. The cost would average well over $150 a month, with patients taking 10-12 pills per day. We knew there had to be a better, more cost-effective way to deliver the necessary nerve nutrients. That led us to our formulation – NUPHORIA cm Gold

Most Effective Formula for Nerve Support

NUPHORIA cm Gold is loaded with B vitamins, but not just ordinary over the counter B vitamins. Many B vitamins come in different forms. Using an inappropriate form of the B vitamin makes all the difference in the level of effectiveness for a nerve support supplement. Many nerve support companies will use the least expensive B vitamins, which commonly are the wrong form to elicit nerve repair.

Here Is What Makes Our Ingredient Formulation Superior To Others On The Market.

Based on the specific forms of nutrients that we use, and how we complex them together for a synergistic effect, our formulation has a 5x Greater Absorption Rate (bioavailability) than any other nerve support supplement.
Let’s look at how our formulation differs from other nerve formulas on the market.

Vitamin B1

Benfotiamine

Many nerve supplements contain vitamin B1 in the form of thiamine. Research has shown that thiamine, a water soluble form of B1, is less effective at long term nerve repair than its counterpart Benfotiamine, a fat soluble form of B1. Because, thiamine is a water soluble vitamin, most of it gets lost in your urine before ever making it to the nerve. That’s not the case with a fat soluble vitamin like Benfotiamine. Furthermore, research found that Benfotiamine also had the ability to protect peripheral nerves from further damage, while thiamine did not.(1)

One clinical study revealed that Benfotiamine out-performed Thiamine by 3.6 times the bioavailability or absorption rate, making it the superior choice in repairing nerve damage. (2)

“Reserch Revealed Benfotiamine Has 3.6 Times Bioavailability (Absorption) Making It The Superior Choice In Repairing Damaged Nerves.”

Vitamin B6

Pyridoxal 5’ Phosphate

Vitamin B6, much like B1 can be found in 2 forms: Pyridoxine HCL or Pyridoxal 5 Phosphate. Other nerve supplements use Pyridoxine HCL, a lower grade of Vit. B6 with a lower bioavailability (absorption rate) because it is less expensive. Pyridoxine HCL, when taken in high doses can cause nerve damage. We use Pyridoxal 5’-Phosphate in our formula because it is easily to absorbed into the cells (high bioavailability) and is has never been shown to have side effects or cause nerve damage, even when the dose is 7000 mg.

Pyridoxine HCL, also, must be converted in the liver to Pyridoxal 5 Phosphate, the more usable form of B6. This can be difficult to achieve in seniors or people with digestion problems, poor liver function, celiac disease, and children with autism. As a result, although they are taking B6 it never becomes available for use by the cells of the body. (3) Another problem with B6 in the form of Pyridoxine HCL is that it can often cause stomach upset or nausea. In our formulation, we use 80 mg of Pyridoxal 5 Phosphate as a therapeutic dosage. This form of vitamin B6 is the most bioactive and usable form requiring no conversion for cellular use. With this form, full benefits are available immediately after absorption and no stomach upset, no nausea. Pyridoxal 5 Phosphate is the superior choice for effectiveness.

Vitamin B12

Methylcobalamin

The human body is incapable of producing its own B12 vitamin. As a result, we are completely dependent upon acquiring it from outside sources, such as food and supplements. Most B12 supplements will exist either as Methylcobalamin or Cyanocobalamin. Cyanocobalamin contains a molecule of cyanide, so in order for the body to use it, the liver must first remove the cyanide molecule. As a result, the body struggles to absorb the cyanocobalamin. Methylcobalamin, however, is easily absorbed by the cells of the body, especially the nerve cells. According to the National Institute of Health, methylcobalamin is the most absorbable and bioavailable form of vitamin B12 and superior to formulation that only contain cyanocobalamin. (4) Our formulation of NUPHORIA Gold contains a therapeutic dosage of 4000mcg per day. This dosage has been bound in research to have a significant affect on nerve repair and regeneration.(5)

R-Alpha Lipoic Acid

Alpha Lipoic Acid (ALA) is a powerful antioxidant and plays a key role in the cell transport of glucose. It can be found in 2 forms, R-ALA or S-ALA. Most supplements utilize S-ALA because it is less expensive, however this is a synthetic form making it completely ineffective in nerve repair.(6) Research has shown that R-ALA is 12x more effective than S-ALA

Proprietary Blend of Natural Synergistic Ingredients

Proteolytic Enzymes

More than 70 million Americans suffer with a wide variety of digestive disorders. These disorders range from minor symptoms like excessive gas & bloating, acid reflux (heartburn), to more chronic and even serious conditions, such as GERD, Irritable Bowel Syndrome, Diverticulitis, Crohn’s disease, Ulcerative Colitis, and Celiac disease. Because of this, when taking vitamins and supplements it becomes very difficult for the body to absorb the nutrients into the cells for use. As a result, many supplements are never utilized by the body and are lost in your urine or feces.
Since we realize this is a widespread problem across the United States, we have created a synergistic blend of proteolytic enzymes within our NUPHORIA Gold supplement to ensure that the essential nutrients are utilized for nerve repair and regeneration.

What Are Proteolytic Enzymes?

Proteolytic enzymes aid in the process of digestion to help break down food content, especially proteins. These enzymes are necessary to assimilate all of the vitamins and minerals we take into our body, either through food or supplements. Vitamin B-12 absorption is dependent on digestive health. In order for B-12 to be broken down to be used by the cells you must have the ability to produce digestive enzymes in your gut. People who are on medications for acid reflux or Gerd have their stomach acid inhibited. This is a major benefit of placing proteolytic enzymes within our formulation.
The other benefit of proteolytic enzymes is that they decrease inflammation within the body and help protect the cells from damage due to inflammation.

We are proud to say that we are the ONLY Nerve Formulation that utilizes proteolytic enzymes to ensure the absorption of the nutrients within our formula.

Sea Kelp

Sea Kelp is an important part of our proprietary blend. Let’s take a look at the role it plays in the body.
Kelp is a form of sea weed find in shallow ocean waters. It is considered a natural superfood loaded with trace minerals and minerals, vitamins, and amino acids. It is also a natural source of Iodine.
The United States Department of Agriculture (USDA) states that Americans are deficient in many critical vitamins and minerals.

Facts released by the USDA and CDC (7)

• 9 out of 10 Americans are deficient in potassium
• 8 out of 10 are deficient in vitamin E
• 7 out of 10 are deficient in Calcium
• 50% of Americans are deficient in vitamin A, C and Magnesium
• 30% of Americans are deficient in Iodine
• 25% of population deficient in Iron

All of these nutrients (vitamins, minerals, amino acids) play a critical role in cell function and healing. Based on these statistics, we felt it was imperative to add Kelp to our formulation, in order to achieve the best results in cellular repair.

Kelp also has these other Amazing Benefits: (8)

• Has Anti-Inflammatory Properties
• Aids in Blood Sugar Control
• Most Potent Source of Iodine
• Helps detoxify harmful chemicals from the body
• Boosts the Immune system

References

• Stracke H1, Hammes HP, Werkmann D, Mavrakis K, Bitsch I, Netzel M, Geyer J, Köpcke W, Sauerland C, Bretzel RG, Federlin KF., Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats., Exp Clin Endocrinol Diabetes. 2001;109(6):330-6.
• Loew D1., Pharmacokinetics of thiamine derivatives especially of benfotiamine., Int J Clin Pharmacol Ther. 1996 Feb;34(2):47-50.
• L Lumeng, A Lui, and T K Lim, Plasma content of B6 vitamers and its relationship to hepatic vitamin B6 metabolism., J Clin Invest. 1980 Oct; 66(4): 688–695. doi: 10.1172/JCI109906
• Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press, 1998.
• Idiris Altun, M.D.* and Ergül Belge Kurutaş, Vitamin B complex and vitamin B12 levels after peripheral nerve injury, Neural Regen Res. 2016 May; 11(5): 842–845. doi: 10.4103/1673-5374.177150
• Hagen et al, "(R)-alpha-Lipoic acid-supplemented Old Rats Have Improved Mitochondrial Function, Decreased Oxidative Damage, and Increased Metabolic Rate," FASEB J 1999 13:411-418
• Bailey RL, Dodd KW, Goldman JA, Gahche JJ, Dwyer JT, Moshfegh AJ, et al. Estimation of total usual calcium and vitamin D intakes in the United States. J Nutr. 2010;140:817–822.
• Kim SK, Bhatnagar I. Physical, chemical, and biological properties of wonder kelp–Laminaria. Adv Food Nutr Res. 2011;64:85-96. PMID: 22054940